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Accounts of Chemical Research, Vol 36, Issue 09
Cover Page
Cholesterol oxidase modelled in contact with cellular membrane and
cholesterol
Sampson NS & Vrielink A. Cholesterol Oxidases: A Study of Nature's
Approach to Protein Design.
Acc Chem Res. 2003, 36,
713-722 HTML/PDF
Lyubimov, A.Y., Heard, K.,
Tang, H., Sampson, N.S. & Alice Vrielink, A. (2007).
Distortion of
flavin geometry linked to ligand binding in cholesterol oxidase.
Protein Science, in press.
Moustafa, I. Foster, S. Lyubimov, A. Y.
& Vrielink, A. (2006).
Crystal structure of LAAO from Calloselasma rhodostoma with its substrate and
substrate analogue: impacts on the mechanism.
Journal of Molecular Biology,
364, 991-1002.
Lim, L., Guinn, N., Molla, G., Ghisla, S., Pollegioni, L. & Vrielink, A.
(2006).
Structural and kinetic analysis of the H121A mutant of cholesterol oxidase.
Biochemical Journal,
400, 13-22.
Lyubimov, A.Y. Lario, P.I., Moustafa,, I. & Vrielink, A. (2006).
Atomic resolution crystallography reveals how changes in pH shape the protein
microenvironment.
Nature Chemical Biology,
2, 259-264.
Vrielink, A., P.I. Lario & Lyubimov, A.Y. (2005).
The crystal structure of cholesterol oxidase at atomic resolution: A study of
the catalytic mechanism.
in: 'Flavins and Flavoproteins 2005, (Eds T. Nishino et al.) ARchiTect Inc.
Tokyo
pp 71-80.
Vrielink, A., & Sampson, N.S. (2003).
Sub-Ångstrom Resolution Enzyme X-ray Structures: Is Seeing Believing?
Current Opinion in Structural Biology, 13, 709-15. HTML/PDF
Lario PI, & Vrielink A. (2003).
Atomic Resolution Density Maps Of the Backbone Carbonyl Groups Reveal
Secondary
Structure Dependent Differences in Electronic Distribution.
Journal of the American Chemical Society, 125, 12787-94. HTML/PDF
Manjasetty BA, Powlowski J, & Vrielink A. (2003).
Crystal structure of a bifunctional aldolase-dehydrogenase: sequestering a
reactive and volatile intermediate.
Proc Natl Acad Sci U S A.,
100, 6992-7 HTML/PDF
Lario PI, Sampson N, &
Vrielink A. (2003).
Sub-atomic Resolution Crystal Structure of Cholesterol Oxidase: What
Atomic Resolution
Crystallography Reveals about Enzyme Mechanism and the Role of the FAD
Cofactor in Redox Activity.
Journal of Molecular Biology,
326, 1635-50 HTML/PDF
Ye, Y. Sampson, N.S.,
Vrielink, A., & Lario, P.I. (2001).
The presence of a hydrogen bond between asparagine 485 and the pi system
of FAD
modulates the redox
potential in the reaction catalyzed by cholesterol oxidase.
Biochemistry 40,
13779-13787. HTML/PDF
Geyer, A.,
Fitzpatrick, T.B., Pawelek,, P., Kitzing, K., Vrielink, A., Ghisla, S. &
Macheroux, P. (2001).
Structure and characterization of the glycan moiety of L-amino acid
oxidase from the
malayan pit viper Calloselasma rhodostoma.
European Journal of Biochemistry, 268, 4044-53. Abstract
Coulombe, R., Yue,
K.Q., Ghisla, S. & Vrielink, A. (2001).
Oxygen access to the active site of cholesterol oxidase through a narrow
channel is gated by an Arg-Glu pair.
Journal of Biological Chemistry 276, 30435-30441. HTML/PDF
Pawelek, P.,
Cheah, J., Coulombe, R., Macheroux, P., Ghisla, S. & Vrielink, A. (2000).
The structure of L-amino acid oxidase reveals the substrate trajectory
into an
enantiomerically conserved active site.
EMBO Journal
19, 4204 - 4215. HTML/PDF
Ahvazi, B.,
Coulombe, R. Delarge, M., Zhang, L., Vedadi, M., Meighen, E. & Vrielink,
A. (2000).
Crystal structure of the NADP+ dependant aldehyde dehydrogenase from Vibrio
harveyi.
Structural implications for cofactor specificity and affinity.
Biochemical Journal 349, 853 - 861. HTML/PDF
Kohls, D., Sulea,
T., Purisima, E., MacKenzie, R. & Vrielink, A. (2000).
The crystal structure of the formiminotransferase domain of
formiminotransferase-Cyclodeaminase: Implications for substrate channeling in
a bifunctional
enzyme.
Structure 8,
35-46. HTML/PDF
Yue, K.Q., Kass,
I.J., Sampson, N.S. & Vrielink, A. (1999)
Crystal Structure Determination of Cholesterol Oxidase from Streptomyces and
Characterization of Key Active Site Mutants.
Biochemistry,
38, 4277-4286 HTML/PDF
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